In which situation would use of a non-opioid drug be most appropriate?Following a knee…

➤ How should non-opioids be used after knee replacement surgery?
Use non-opioids as part of multimodal analgesia after knee replacement. Scheduled acetaminophen and NSAIDs reduce pain and opioid consumption. Combine them with regional anesthesia, local infiltration, and short opioid courses when needed. This approach improves mobility, shortens recovery, and reduces opioid-related nausea and sedation.