➤ When should a clinician choose one antidepressant class over another?
Choice depends on symptoms, comorbidity, and side effects. SSRIs are first-line for depression and anxiety. SNRIs help when pain or neuropathy coexists. TCAs can treat severe or painful conditions but carry cardiotoxic risk. Bupropion suits fatigue and smoking cessation. Mirtazapine helps insomnia and poor appetite. Reserve MAOIs for refractory or atypical cases.
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