➤ Why does aldosterone lead to potassium excretion?
Aldosterone stimulates Na+/K+-ATPase and increases lumen-negative transepithelial potential. It also upregulates apical potassium channels (ROMK), promoting potassium secretion into the urine. The combined effects lower serum potassium. This mechanism maintains potassium balance and affects cardiac and neuromuscular electrical stability.
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