Seizures are initiated by.hyperexcitability of neurons.closure of the voltage-dependentsodium )…

3. How do voltage-dependent sodium channels influence seizure generation?
Voltage-dependent sodium channels control action potential initiation and spread. Gain-of-function mutations or defective inactivation increase persistent sodium current and promote repetitive firing. By contrast, channel closure or pharmacologic blockade reduces excitability; many antiseizure medications stabilize the inactivated state to limit seizure propagation.