The most important chemical properties of medications related to drug absorption include the…

➤ Why does lipid solubility matter for membrane permeation?
Lipid solubility, often expressed as log P or partition coefficient, controls a drug’s ability to cross cell membranes by passive diffusion. Higher lipophilicity increases membrane permeation but may reduce aqueous solubility and cause tissue accumulation. Effective absorption balances lipophilicity with enough water solubility for dissolution and transport in biological fluids.