➤ How do dopamine and norepinephrine differ in their roles for ADHD symptoms?
Dopamine mainly affects reward processing, motivation, motor activity, and cognitive flexibility via striatal and prefrontal circuits. Norepinephrine, from the locus coeruleus, supports sustained attention, vigilance, and response inhibition in the prefrontal cortex. Dysfunction in both systems produces the combined attention and behavioral control problems seen in ADHD.
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